I figured out how to activate the Dyslexic Mode
introduced in firmware 4.33.19608.
In your Kobo eReader.conf file, under
[ApplicationPreferences] enter:
It will make the UI use the
OpenDyslexic font.
A caveat is that you
need to have the OpenDyslexic font in your system partition (i.e. /usr/local/Trolltech/blahblahblah). If you deleted it or only have a copy in /mnt/onboard/fonts, it won't work (although I wonder if a patch could be made to change the file path it looks for the font at; I assume it's hardcoded).
The good news is that you can drop in the newer
r3 version of the rewrite of the font that has extra glyphs and language support and it still works.
And (although I haven't tried this myself) if you wanted to have the UI show traditionally unsupported characters like Cyrillic or Vietnamese, I think if you take your favourite font that has that support (ex. Noto Sans) and change the internal font name to OpenDyslexic and replace the stock version with it, it will display that instead.
Hopefully, this is a stepping stone to Kobo allowing us to change the UI font officially without having to use patches or internally rename fonts.