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If the end result is to be an epub, InDesign is a silly place to start. It encourages you into a type of meticulous page-based layout that is quite unsuited to ebooks which must be readable on a variety of devices with different screen sizes and different user preferences for orientation, text size etc.
When a book has been prepared for print using InDesign, we may be stuck with translating that format to epub. But don't CHOOSE all the problems that brings if you don't have to!
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