Error: Error communicating with device

[SalShearer]

My Kindle Paperwhite has suddenly stopped connecting to Calibre. I've never had a problem with it before in all the time I've been using it. Today, I plugged it in and got the following error:

calibre, version 2.19.0
ERROR: Error: Error communicating with device

Failed to access files in the main memory of your device. You should contact the device manufacturer for support. Common fixes are: try a different USB cable/USB port on your computer. If you device has a "Reset to factory defaults" type of setting somewhere, use it. Underlying error: [Errno 13] Permission denied: 'O:\\driveinfo.calibre'

Traceback (most recent call last):
File "site-packages\calibre\gui2\device.py", line 87, in run
File "site-packages\calibre\gui2\device.py", line 463, in _get_device_information
File "site-packages\calibre\devices\usbms\driver.py", line 109, in get_device_information
IOError: Failed to access files in the main memory of your device. You should contact the device manufacturer for support. Common fixes are: try a different USB cable/USB port on your computer. If you device has a "Reset to factory defaults" type of setting somewhere, use it. Underlying error: [Errno 13] Permission denied: 'O:\\driveinfo.calibre'

I've tried rebooting it, I've tried a different USB port, same issue. Is the only option to factory rest it?

Thanks for any help you can give. C=