There's almost no way to get a PDF like that looking good on your reader. I'm not sure you'd do much better than just holding down the magnify button to switch into landscape mode (--err, that's how it works on the 505, not sure about the 600--), and otherwise keep it as is.
If you don't need the stuff in the left margins, you might use something like
PaperCrop and just split that out as if it were a separate column; the only other tool that might be worth trying is
PDFLRF, but I doubt the results would be much better than with normal landscape mode.