An ebook with minimal formatting (no hard-wired margins, no unneeded embedded font, no fancy alignments...) is almost guaranteed to be decently rendered and readable in pretty much any reader.
An ebook with lots of bells and whistles that try to make it look as close as possible as the printed book in some particular reader/format, is almost guaranteed to fail miserably and produce an unreadable piece of cr... text in some other reader, or with some particular set of preferences (some people like reading in landscape, or with large font...).
So, my advice is to be rather minimalistic as far as formatting goes, and only add other "nice" stuff after considering how it will look in readers that do not support that feature, or with wildly different settings.
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