in PRSPlus\epub\ i made a .CSS with:
@font-face { font-family: serif; font-weight: normal; font-style: normal; src: url(res:///Data/fonts/CaeciliaLTStd-Bold.otf);}
@font-face { font-family: serif; font-weight: normal; font-style: italic; src: url(res:///Data/fonts/CaeciliaLTStd-BoldItalic.otf);}
@font-face { font-family: serif; font-weight: bold; font-style: normal; src: url(res:///Data/fonts/CaeciliaLTStd-Heavy.otf);}
@font-face { font-family: serif; font-weight: bold; font-style: italic; src: url(res:///Data/fonts/CaeciliaLTStd-HeavyItalic.otf);}
body {font-family: serif;}
body, body.calibre, body.calibre1, body.calibre2, body.calibre3 {font-size: 0.85em !important;}
thx to jackie_w for helping me