I think the only safe way is to preserve your original files together in a folder and produce what is needed at the time.
Some devices have hi-res displays, but their users don't buy books for them so much. If you keep the largest original files, you can pretty easily knock out low res ones in an epub, rename the high res ones and add them to the epub or use a program that can do bulk resizing or bulk change in resolution for something in between.
Ebooks are hot right now, but whether they last for another ten years, who knows?
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