I haven't a clue. All a calibre instalaltion does is install a few icons, a few completion files and a few .desktop files. And even that it does using the xdg tools, not by itself. I dont see how it is possible for that to "hose" a desktop environment.
But you dont have to take my word for it, the calibre isntaller is open source, read it for yourself:
https://github.com/kovidgoyal/calibr...libre/linux.py