I used to TRY to edit epubs in Calibre , but that sort of thing isn't really in my skill set.
I use CoolReader for non-library books. When a book is first opened, I go to CSS settings and uncheck the "enable document internal styles". Then the book displays with the presets I previously established. (Like left justify only, line spacing, paragraph spacing, font style and size, margins. Lots of stuff. )
I know a lot of people don't care much for CoolReader, and the app has some real shortcomings, annoying shortcomings, but I use it pretty much exclusively for my non-drm'd epubs. They look the way I want them to. And I don't have to struggle to edit them.
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