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"Geht's los?" means as HarryT said "Has it started?". Are you shure about the second phrase? Maybe it is a typo or just odd/old usage. But it should read "Was sein muss, muss sein". This means "What has to be, has to be", or "What has to be done, has to be done". More likely the second one is what is meant. It is a common phrase in german.
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