Thanks for these points. I hope some expert will be able to sort this out regarding pyftsubset.
For the time being, I modified the top posts of this thread to add that, due to the fact that we make it work currently with a single list of characters, pyftsubset can provide a size saving advantage if the book use only both regular and italic fonts. This advantage could be greatly reduced, even nullified, if we had to include bold and bolditalics fonts.
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