I would suggest that before you slap this ePub with a batch resize you should take a look at the image sizes and see if there is a set, possibly small in number, of "bad apples".
Since an ePub is a ZIP container you could do the following:
- Create a copy of the ePub
- Change the copy's extension to ".zip"
- either Extract the contents or simply view the contents of the ZIP (depends on the abilities of your OS)
- Sort the "/images" folder by size
- View the sizes
With some OSs you'll have to Extract the files to get full control of how the folders are displayed. You might find that there are only a limited number of images that need most of the work.