You should set the Calibre output profile to tablet so you do not modify the images. The Kindle PW1 & 2 are higher resolution screens and the Voyage is an even higher resolution screen. So you do want the images high resolution. Plus, you should convert to AZW3 and not Mobi. Mobi is obsolete and for the higher resolution screens, AZW3 is much nicer.
To change the output profile to tablet, do the following... Preferences | Common options | Page setup | Output profile | Tablet. The output profile of tablet does not modifed the images at all. It leaves them alone which is what you really do want. Even on a lower resolution device such as the Kindle Keyboard and Kindle Touch, higher resolution images look better when scaled down.
There is a program called ePUBOptimizer (do a search for it on MR) that will subset TTF fonts and reduce the size of graphics (without changing the quality) for ePub. You do that and then you convert to AZW3 and you'll have a smaller resulting eBook.
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