Since it is not easy to repurpose the disk space on /system partition for any other use I would suggest the safe way:
Code:
adb shell pm uninstall --user 0 org.package.name
This command should prune all /data/data/org.package.name files and remove the app from your launcher/list of installed apps. It does that without affecting the /system partition or any of the overlays used by vendors/oem, so it is safe to uninstall apps as long as your device has a working recovery mode that lets you do a factory reset.