@AlanHK - It does sound like a DLL Hell type problem, but that was last century.
What else is running? Maybe some Qt4 based software?
I would close down all discretionary applications - weather alerts, email, RSS clients, diary, browsers etc - and see if I could induce the behaviour. Given you're the only person with the problem (that we know about) suggests its something specific to you - which could be the software set you're running.
I think the only registry entries for Sigil are those the installer puts there for the uninstaller, plus any shell related entries for file associations the user sets up - eg for epub open with. Everything else is in D&S - Preferences has a button that opens it.
You could try running Sigil in Sandboxie - if behaviour in there is OK then that would suggest its a another application scribbling something where it shouldn't. Do you have any oddball driver's - analogue i/o, process i/o.
BR
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