The Windows MobiPocket Reader also has a 2-page display option and a "paper book aspect ratio" option.
The same things that help on a small LCD screen may help on a large screen. Some people find a dark background is best and colored (vs white) text, others like a colored background with black text. Also reducing the brightness may help. The Windows MobiPocket Reader can adjust these properties, but other reader software may be able to do an equally good job. You should also minimize glare off the screen from lights and windows.
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