advantage for nook, or any android device, is that you don't need itunes or run a calibre server (or any other) to transfer books to your device. any computer or any website where you download books will do. plus if you want to use another ebook reader you don't have to have a copy of the book for every reader.
i have both and have a use for both. i prefer the nook for reading b/c of the convenience of being able to transfer files far more easily from any computer. plus with fbsync i can sync fbreader with all my devices.
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