Kovid was correct. It is my anti-virus program. Hadn't considered this as it had not interfered with calibre in the last year and I had not update the program. Interesting in that my anti-virus program ESET NOD32 does not allow the program to run. Gives me a message of a python error. I tried to put in an exception for the program file calibre, but this doesn't do the trick. Any suggestions.
So far the simple work around is to close the anti-virus, load calibre and then I can turn it back on.
Thanks for all the help.
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