I did the above test. Kindle imposes 20 pixel margins on left/top/right; 25 pixels are used on the bottom by the progress panel and some additional margin there. So the display area is exactly 560 x 755.
If the 600x800 screen is 3.5" x 5.25", then the PDF viewing area is 3.5*560/600 by 5.25*755/800, or about 3.27" x 4.95".
At some point, I'd like to generate a PDF picture portfolio where the image dimensions are 560x755 and/or 1120x1510, and verify that all of the pixels get displayed without any rescaling artifacts.
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