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Sarah Dunant has written very readable Renaissance novels set in both Rome and in Florence, with In the Company of the Courtesan (Rome) and The Birth of Venus (Florence).
Leonardo's Swans by Karen Essex is set in Milan, and is a fictional account of the d'Este sisters. Another really good novel about Beatrice d'Este is The Duchess of Milan by Michael Ennis, but I don't know if it's available as an e-book.
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