If size of character is not important, I like New Century Schoolbook. It is a serif font that is very easy to read since it is so open. It also has a low letter count per inch vs. Times or Ariel (which is also a lower count that Times.) The hardest font for me to read is Baskerville (or New Baskerville) since after a few minutes my eyes start to hurt. Generally I find that a serif font is easier to read for me than a san serif.
For size I tend to ~11 pt for the body copy on the Sony Reader. I use the built in Dutch (Times) font for body copy and Swiss (Helv or Ariel) for titles.
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