Yes, over brightness, too contrasty, wrong gamma and glossy are all tiring.
Glossy is the biggest cause of eye strain and headaches as you unconsciously re-focus on the reflected image. Plain non-gel tooth paste can reduce the gloss (don't try on a touch screen). Make sure the screen is clean first. Use a pea sized piece and no water.
Make sure no lights or window reflecting off a screen. Right angles approximately and/or a diffusing light curtain.
Don't use screen in too dark a room. Lighting should be good enough for a small print yellowed paperback book, but never ever shining on or reflecting off the screen. Working to the side of a room light.
Too big a screen is a problem for reading glasses (field of view). Also reading glasses are for book distance. A screen can easily be too far away. Sit closer to desk and have screen close. You might also need to raise a screen. I have a 2.5cm approx support at the rear of the laptop to slope the keyboard and raise the screen. I also find the laptop needs to overhang the desk by about 1cm so that the screen is close enough.
Absolutely turn any light sensors or dynamic contrast off on ANY screen, TV included. Use a fixed lighting level.
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