Though I prefer to edit using Sigil's excellent tools and features, if Kindle is your end-point you may find a conversion (even an EPUB > EPUB one before using Amazon's own conversion using Kindle Previewer) in Calibre a good idea.
It can add a few useful 'tricks of the trade', things like Kindle not recognizing a zero line indent, preferring a minimal non-zero figure. And I've known perfectly compliant EPUB code presented to LuLu (I know, but I have clients who favour that distribution platform) be rejected for no discernable reason, but accepted after a Calibre conversion.
But do it as a very final procedure, and retain the Sigil version. Clean, un-cluttered code is not an invariable feature of a book that has passed through Calibre!
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