The weight of the motion is the main drawback (after price.) The units almost need to be disposable which indicates fewer features for a portable version and more features and weight (along with non-disposability) for a base or home version.
I have long maintained that one of the main reasons that ebooks did not take the market by storm was that people are not comfortable reading a verticle screen as one would on a desptop or laptop computer. Only when the surface is flat (or held in the hand as with the Sony Reader for example) does the reading become normal and therefore more relaxed. For study and notes this requires a surface to place the unit while in use.
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