This is a huge issue when it comes to designing eReaders, actually.
With the iPhone, I switch hands alot when using it. What I love about Stanza is, they let you set the "page forward" tap to be not just left side, or right side, but BOTH (to go back a page, swipe works fine). I wonder if the other eBook readers ever bothered to test this stuff. Going to preferences to change the tap zone every time you switch hands to use something is just ridiculous.
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