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What I do is if the images are larger enough then 1600 lines, I reduce down to 1600 lines. If they are not JPG, make then JPG. In Calibre, you can do a lossless compression to remove any rubbish in the images.
If there are embedded fonts, in Calibre, you can do a font subset to reduce the size of the fonts and remove any unused fonts.
Once you have the eBook as small as possible and it's still too large, then solution from there is to just deal with it as is.
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