Thanks, GeoffC!
I think I figured out what the problem was. It had to do with the HTML I had generated in Adobe Acrobat. For some reason, calibre didn't like the <SPAN style> tags containing the font size info.
I went back to the original Word file, saved as HTML (filtered) and then processed with Mobipocket Creator, and the different font sizes were retained.
Incidentally, Mobipocket Creator didn't like the <SPAN style> tags either.
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