I haven't noticed any huge problems with mine, but there is a pinprick-size spot of high brightness, literally just a single pixel in size, in the lower right corner. I only noticed because it was right near the "page X of Y" listing when downloading my book library. It's not enough to make me exchange the Kindle, though.
There is a little unevenness at the bottom, but it was expected given reviews I've looked at -- it's to be expected given the way the lighting works.
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