All my apps, photos, movies, podcasts, iBooks, etc are in iTunes. I regularly sync between iTunes and my iPad - syncing is fine and very fast. There's nothing on my iPad I need a backup for that isn't already in iTunes or on media I already have sufficient backups for. I've erased my iPad twice within in the first couple weeks of owning it and all I did was attach it, give it a name and have it sync my iTunes.
Compared to the multi-hour backups it tries to perform daily, I'll add my wpa key if I have to start fresh myself and deal with my own backup methods.
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