Hi there. Glad I decided to search first because I am having the exact problem. Last week nothing the matter. I was using calibre 64 a lot. Yesterday I wanted to run and my pc gave me the message that this app can't be executed on this pc (translated from Dutch)
So I tried in admin mode and will now try in safemode but I think this happened because of a windows update or so because I did nothing to have this occur. Windows 10 and I have a 64 based windows and my calibre which I can't open is 64 bit.
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