I want to maximse the number of words per screen (thus minimising the number of page turns), so I use 10 for left and right, and 0 for top and bottom. I don't use 0 for left and right because I find characters can be difficult to read when they are right up against the left and right sides of the screen. This doesn't seem to be a problem for top and bottom though, so I use 0 there.
I also use 8 pts base font size. On small zoom, this is just about readable for me. If my eyes are tired/the lighting is not great, I can zoom into medium, which gives about 10 pt size. I never use the large zoom.
I convert to LRF not ePub--the latter does not have full justification on the PRS.
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