Well ... so far I love my Kindle. I haven't had any problem holding it and hitting the buttons I want to hit with one hand.
There have been only two deficiencies for me:
1. The cover, which I hate ... but which has inpired me to creat my own;
2. The Kindle Store ... which for some reason will NOT connect for me. This, despite the fact that the browser is working just fine thank you very much and I LOVE being able to get wiki information so easily (I'm taking it to all the cocktail parties I attend from now on .... the ability to slap down other know-it-alls will be worth the price).
Oh .... I forgot, I don't get invited to cocktail parties. Oh damn.