A DX is not that heavy. My mom has survived lung cancer, thyroid issues, and a series of heart problems all while using a DX. The larger screen allows more text on the screen, which is very nice. My parents have flat out said they would. Not use a smaller ereader because it would be too small.
It depends on the person and their preferences.
The ease of buying boos from Amazon and the large number of available make a Kindle a great option. If the user is not computer savvy, having access to a larger number of boos from the device itself is a plus. Toss in the 3G capability on the DX And you have a device that is easy to use, read, and buy off of wherever she is.
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