The U.S. Dept. of Justice and Dept. of Education have written a joint letter to colleges and universities warning them that ereading devices violate the Amercans with Disabilities Act. " Many e-readers have text-to-speech functions, but those don't apply to menus, which means that a blind person would still need help using the device," said a spokesperson.
http://www.katu.com/news/tech/97425114.html
This should put the firmware developers into overtime. They will need to have the device talking right from start-up. And it probably means braille showing up on device buttons soon, too.