I use a 3.4", a 5" and a 7" reader. Yes, I do turn pages more often on my 5", but I don't really notice it. The device has paging buttons on the right, left and bottom side, so, the pushing goes automatically and I don't have to switch positions.
My 3.4" is the older, then the 7" and finally I bought the 5". I bought it mostly because it's e-ink (the other two are LCD-based), and I figured 6" would be too large to take with me comfortably.
And how I hold my device? Depends on where I am. In bed, I often hold the device by its side, in the hammock on the bottom, when I'm eating, I often prop it up against something, and it's usually standing propped up against my monitor when I'm sitting behind my PC.
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