I agree that one-handed use of the Nook is difficult. I'm considering the soft root to switch the buttons, but I've been pretty happy using the Nook in an easel style case, and using the touchscreen to page turn.
It's funny (to me) that you find the Sony PRS-600 more one-hand friendly. I used the PRS-700, which has a similar design/weight, and I found it MORE uncomfortable for one-hand than the nook - the bottom buttons dug into my fingers, and holding it from the bottom made it top heavy. I tried to one-hand and use my thumb on the touchscreen, but couldn't quite master it without feeling like the 700 was insecure.
The PRS-300 is very one-hand friendly.
It's a good thing there are lots of hardware designs. That is my fear with e-Ink market consolidating - we'll have less hardware choices. It already stinks have no pricing options anymore.
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