I'm right handed, but nearly always hold my 300 in my left hand, thumb stretched across to the right arrow key. If feels so natural I don't even notice it. My hands are medium sized, but my fingers are long, so YMMV. My wife has smaller hands than me, and her 600 (bigger) has the Sony cover w/light, so she usually uses 2 hands, but I've seen her use one pretty often, with the cover folded back (touch screen means she doesn't need to stretch).
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