I only put epub files onto my PB302v15.2, and the handful that I didn't get as epub originally are converted from .prc or .html. Nothing on my PB302 has DRM. I don't pass any special CSS into the renders via calibre.
I've never had any excessive latency opening a file, with the exception of books from OReilly but that's a known issue with their TOC or something.
Have you tried a known good epub that didn't go through calibre? If you're using fbreader180, have you fiddled the settings into something irrational that requires massive rendering? Have you tried other formats besides PDF? Do you have trouble rendering the photos?
If you haven't already, do a hard reset to restore default settings and try it with a known good epub stored in device memory. If the problem persists, there well could be something going on with your hardware.
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