Quote:
And I can easily imagine a society in which humans do not have a desire, or a need, to "get a high" from any substance... not to mention an ability to create "synthehol"-type products at will, taking the "high" out of alcohol.
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But we're still talking about humans, aren't we?

Even animals enjoy alcohol on this planet - at least as fermented fruits - so this is basic to our genetic structure. This won't change.
The substance might change, but not the being consuming it.
* my bottle of Californian Chardonnay is empty, grumble ...