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As others have said, alcohol has been the drug of choice for humanity for several thousands of years. It is literally older than civilization. Now, this doesn't mean it won't make sense for it to disappear someday, but it is definitely deeply entrenched and it would be hard to imagine it would go away easily. The further removed from present society your setting is (in terms of time, relevant technology, and societal structure), the more believable it will be that alcohol goes away. Still, perhaps your best bet would be to have it be have it diminish in prominence without it being truly gone - somewhat like what has happened to cigarettes.
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