This is a recommended read for everyone who makes websites and who also cares about handhelds.
A List Apart features an interesting
article that deals with the question how to adjust your webpage to the needs of handheld devices.
Co-written by Jorunn D. Newth from Opera Software, the article first examines the constaints of a handheld device (small screen, limited input, slow downloading, slow processor, limited memory) and then explains how a webdesigner can scale-down his page to take these constaints into account (mainly through HTML optimization and special CSS markup).
I know MobileRead is still lacking full support for mobile devices; trust me, implementing it ranks very high on my list of to-do's!