How big is the file? It may just take awhile for the initial loading of the document due to the size. Or there could be a problem with the file itself. Have you tried opening it in something like Calibre's ereader on your computer? If it won't open there either then there's an issue with the file and you'll either need to reconvert if you converted it to epub yourself or redownload it from the original source. Hope that helps.
Beth
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