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The eye fatigue conversation reminded me of something I learned recently, which I thought I'd mention. As we get older, our eyes have a harder time adjusting quickly to changes in focus. That is, if you have good eyesight you can still see well after your eyes have focused at a particular distance. But the transition from one focal length to another can take longer for older eyes. This different from nearsightedness; it's called "presbyopia". Eventually it becomes a permanent farsightedness, requiring the use of bifocals.
Anyway, the resolutions of the iPad (132ppi) and the Kindle DX (150ppi) are fairly similar, but clearly they are different enough to have an effect. My iPad works fine for me, but I do think it's a bit more tiring than reading on my Kindle. Of course, everyone is different.
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