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As a rule, DRM books can only be opened by their specific programs. For instance, a book from the Sony store can only be opened by the Sony Reader software or Adobe Digital Editions. DRM free software can be opened by any software that can read that format. For instance, I have a FireFox plugin for ePub, but it can only open the DRM free variety.
I may get flamed for this, but I'm not as enthusiastic about the Sony models. The 300 is super stripped down. In my opinion, the Astak Pocket Pro and the PocketBook 360 both offer a lot more options for about the same price. The 505 was an awesome reader, but it's 2+ years old now and no longer being manufactured. You can buy them on eBay, but they've been overtaken by a new generation of devices with faster processors, better grey scale and more features. I've never gotten past the screen on the 600. It's very distracting to me to be able to see my reflection when I'm reading. Having said all that, the Sony does make well designed readers with easy to use firmware.
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