Well, you could sign up to be an iPad developer ($99/yr) and get the development tools, then use the iPad simulator to run iBooks, test it in there. I think. I haven't tried this myself, my Mac development system is at home, and I'm not.
Actually, I re-read your question. You can drag-and-drop any non-DRM epub file into iTunes and sync up your iPad and the book will be in the iBooks application.
I had thought you asked if there was a way to test on a Mac without an iPad at all. No. There is no iBook application from Apple for the Mac (or the PC).
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