Try the Georgia font that comes with Windows for Serif font reading; it is a wee bit darker than average for a normal font and it comes as a full set so you get true italics.
For the bookshelf, try Lucida Brite; it's a wee bit larger than average and very clean; it helps with the status bar and indicia.
Look into Themes (they're installed the same way as Fonts and Apps, you just copy them into the designated folder) they don't just reskin the display, they do alter behavior. Some folks like the Minifred and Lastopen themes available through the various Theme-related threads here. (The opening screen shows the last 10 opened books instead of just 2) Or you can create/modify your own.
Look into alternate button mappings. I would sugest moving paging off the large "wing" buttons and onto the four-way silver rocker; it lets you page forward with a minor increase of thumb pressure and back with a minor thumb movement. In fact, I have the most-frequently-used features mapped to the silver rocker and reserve the wing flaps for the dictionary, note taking, etc
Be careful if you delve into the style-tweaking features of the FBReader180; you can't do any harm but you can lose days and days of your life just seeing what all those dozens off settings do. (Hint: a lot!) Remember, the purpose of the device is to assist your reading, not suck you into format-tweaking.
