I'd hire an estate / tax lawyer
Donate 50% with provisions for spending to a rotating set of hospital / research centers (I'd work with the actual employees and not Board of Directors or Administrators)
Give family members the yearly max gift to families amount.
Purchase and joint title family member's homes, so I could have the tax deductions to continue the yearly max gift to families while they live there for free.
Set up college tuition trust funds for younger family members.
Set up yearly donations for local libraries, senior health centers, and shelters.
There is not much I really want for myself, just make sure I could continue to pay the monthly bills with the rest that was set up in the investment portfolios.
Pretty boring and practical, huh.. This was a game my son and I use to play, as he was growing up. When he was little, it was all about the things he wanted. Later, we began to refine the list to be practical and more realistic. The only thing that would be added by him is the chance to do more traveling.