i've loaded some 500 epubs out of calibre into ibooks. you can easily change the font size. the smallest size is about that of a typewriter. while it is readable, it's a bit uncomfortable for long reading with my old eyes. there are 5 sizes with the largest being smaller than what my 600 will get up to. i have read several hundred pages at the medium size just fine.
portrait mode presents a single page, which i find easier to read. landscape presents two side-by-side which i find more difficult. to each his own.
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