Indesign to Epub works. Be sure to look at
http://www.adobe.com/products/creati..._software.html and
http://www.adobe.com/devnet/digitalpublishing/. Yes, there are howto videos in the first link.
Do as much as you can from Indesign itself. Usually, if any, there's only minor tweaking left to do in the css style definitions and the epub metadata. Avoid editing the xhtml files manually. That way the epub won't cost more than the print version to typeset.