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I would simply convert the text to ePub-compliant italics, unless there is some particular reason you can't simply use italics (or bolding) for emphasis. Is it exclusively a cultural thing, or does it somehow impact the output or ability to read the document? Does it distort the meaning? If not: When in doubt, go for compliance, I always say. (And contact the IDPF, if you think this is something they should address.)
Alternatively, you could try inserting a d-a-s-h after each character (except the last, which would solve your comma issue). I don't know how screen readers, dictionaries, etc, would be able to handle that, though.
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